The effect of ethambutol on mycobacterial cell wall permeability to hydrophobic compounds.
نویسندگان
چکیده
Ethambutol (EMB), the first line drug in the treatment of tuberculosis, is an inhibitor of the biosynthesis of the cell wall compound - arabinogalactan. It was found that EMB at sub-inhibitory concentration increases the permeability of the M. vaccae cell wall, which was monitored by cell sensitization to erythromycin and rifampicin. The high permeability of the cell wall to hydrophobic compounds allows enhanced intracellular bioconversion of beta-sitosterol to 4-androsten-3,17-dione (AD) and 1,4-androstadien-3,17-dione (ADD).
منابع مشابه
ANDROSTENEDIONE PRODUCTION BY BIOTRANSFORMATION OF PHYTOSTEROL by ALOK KUMAR MALAVIYA
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ورودعنوان ژورنال:
- Polish journal of microbiology
دوره 54 1 شماره
صفحات -
تاریخ انتشار 2005